The Science

Carcinogenic High-Oestrogen

Dr John Lee

Dr John Lee is famous for inventing the term OESTROGEN DOMINANCE after conducting groundbreaking research into the need to have Progesterone – as well as Oestrogen – in the early versions of the Contraceptive Pill after its introduction in 1960. He was the first to list the numerous symptoms of Oestrogen Dominance, caused by the relative lack of Progesterone compared to the high level of Oestrogen, leading to our current understanding of how finely tuned the hormonal system is.


Dr Mercola

‘New Information on Natural Progesterone and Cancer Prevention’ in JAMA January 28 1998
“I had the great privilege of being a speaker at a seminar with Dr John Lee. I was expecting to learn some exciting new information and I was not disappointed. The most astonishing insights had to do with progesterone’s ability to prevent and reverse many cancers. The newer studies show Oestrogen, specifically Oestradiol, does not increase the risk of breast cancer but it actually causes breast cancer. There is not any debate left about this issue. All major researchers have found this.”


Dr David L Watts

Trace Elements and Other Essential Nutrients Trace Elements Inc.Texas 1995
“Estrogen is closely associated with copper; when the level of one rises, so does the other. Zinc is associated with progesterone; the levels of these two also move in tandem. Many women taking oral contraceptives have elevated tissue copper levels. The same is true for women using copper intrauterine devices, since the body absorbs the copper from the copper wire.”


Henry Osiecki

The Physician’s Handbook of Clinical Nutrition, 7th ed Bioconcepts Brisbane p123
“Copper facilitates angiogenesis by inducing the expression of vascular endothelial growth factor in wounds resulting in early contraction and closure of wounds. However copper plays an important role in promoting physiological and malignant angiogenesis. Formation of new blood vessels by a tumour enabling tumour growth, invasion, and metastasis are copper requiring processes.
Copper ions activate several proangiogenic factors, e.g. vascular endothelial growth factor, basic fibroblast growth factor, tumour necrosis factor alpha and interleukin 1.
There is a significant increase in the mean total serum copper levels and the serum Cu/Zn ratio in all patient groups with cancer (lung (PC), breast (BC), gastrointestinal tract (GIC), and gynaecological (GYNC) malignancy) compared to control groups.”


Sherrill Sellman

Hormone Heresy – Oestrogen’s Deadly Truth,
“Another major factor contributing to this imbalance between oestrogen and progesterone is environmental in nature. We in the industrialised world now live immersed in a rising sea of petrochemical derivatives. They are in our air, food and water. These chemicals include pesticides and herbicides as well as various plastics and PCBs. These oestrogen-mimics are highly fat-soluble, not biodegradable or well-excreted, and accumulate in fat tissue of animals and humans. These chemicals have an uncanny ability to mimic natural oestrogen. They are given the name ‘xeno-oestrogens’ since, although they are foreign chemicals, they are taken up by the oestrogen receptor-sites in the body, seriously interfering with natural biochemical changes.
Mounting research is now revealing an alarming situation worldwide created by the inundation of these hormone-mimics. In a recently released book, Our Stolen Future, authors Theo Colburn of the World Wildlife Fund, Dianne Dumanoski of the Boston Globe and John Peterson Meyers, a zoologist, have identified 51 hormone-mimics, each able to unleash a torrent of effects such as reduced sperm production, cell division and sculpting of the developing brain. These mimics are not only linked to the recent discovery that human sperm-counts worldwide have plunged by 50 per cent between 1938 and 1990 but also to genital deformities, breast, prostate and testicular cancer, and neurological disorders.”


Dr Graeme Williams

‘Aromatase up-regulation, insulin and raised intracellular oestrogens in men, induce adiposity, metabolic syndrome and prostate disease, via aberrant ER-a and GPER signalling’, Molecular and Cellular Endocrinology Vol 351, Issue 2, 4 April 2012
Abstract: For some years now, reduced testosterone levels have been related to obesity, insulin resistance, type 2 diabetes, heart disease, benign prostatic hypertrophy and even prostate cancer – often considered guilty more by association, than actual cause – with little attention paid to the important role of increased intracellular oestrogen, in the pathogenesis of these chronic diseases.
In the final stage of the steroidogenic cascade, testosterone is metabolised to oestradiol by P450 aromatase, in the cytoplasm of adipocytes, breast cells, endothelial cells and prostate cells, to increase intracellular oestradiol concentration at the expense of testosterone. …
To understand this fact, that raised intracellular oestradiol levels in men, induce and promote obesity, gynaecomastia, metabolic syndrome, type two diabetes, benign prostatic hypertrophy and prostate cancer, rather than low testosterone, represents a shift in medical thinking, a new awareness, that will reduce the rising incidence of obesity, metabolic syndrome and prostate disease, and significantly improve the health of men worldwide.


Dr Ananya Mandal

‘Prostate Cancer linked to pesticides: Study’ 31 August 2011
“Researchers at the University of Southern California (USC) have found an increasing prevalence of prostate cancer among older men exposed to certain pesticides in Central Valley neighbourhoods. …
Those who lived within 500 meters of places where methyl bromide, captan and eight other organochlorine pesticides had been applied, they found, were most like to have developed prostate cancer. …
The study was funded by the National Cancer Institute, National Institute of Environmental Health Sciences and Department of Defense Prostate Cancer Research Program.”


S V Fernandez and J Russo

‘Estrogen and Xenoestrogens in Breast Cancer’ Toxicology Pathology, 38: 110-122, 2010 in
Abstract: There is growing concern that estrogenic compounds that act as endocrine-disrupting chemicals might potentially have adverse effects on hormone-sensitive organs such as the breast. This concern is further fuelled by evidence indicating that natural estrogens, specifically 17b-estradiol, are important factors in the initiation and progression of breast cancer. …
These studies provide firsthand evidence that the natural estrogen 17b-estradiol and xenoestrogenic substances like bisphenol A (as in plastics) are able to induce neoplastic transformation in human breast epithelial cells.